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Africa

Africa: Ministers from Global South Come Together to Call for Urgent Action on Nature Finance at COP16

todayOctober 31, 2024

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The Ministerial Alliance for Ambition on Nature Finance (MAANF) has today shared a statement signed by 20 Ministers of Environment from the Global South, ‘Seeking Accountability on Ambition for Nature Finance.’ The press conference at which this was launched can be watched here.

Released on the second day of the High-Level segment, the statement calls on countries in the Global North to:

‘Act urgently to ensure that at least $20 billion per year is delivered from developed to developing countries by 2025 and that at least $30 billion per year is delivered by 2030, as agreed in the GBF.’

The statement outlines two specific requests for developed world governments here at COP16 in order to ensure this financial commitment is met:

  1. To urgently deliver new international funding for biodiversity; And
  2. To establish a working group of ministers of environment and finance to focus on fully achieving the $20 billion and $30 billion target on time.

Upon the statement’s release, Hon. Dr. Iziaq Kunle Salako, Minister of State for Environment, Federal Republic of Nigeria, stated:

“Today, we are releasing a Ministerial Declaration endorsed by 20 countries from the Global South to call on developed countries to urgently increase their international finance commitments and to develop a roadmap and accountability mechanisms to ensure that the $20 billion commitment to developing countries will be delivered on time. This is a call to action, and this is an offer to work together to increase accountability and transparency.  Let us be united on the road to ambition – let us work hand in hand to ensure we reach our common goal of fully implementing the Kunming-Montreal Global Biodiversity Framework.

Fellow MAANF Member Hon. Jiwoh Abdulai, Minister of Environment and Climate Change, Republic of Sierra Leone, at the same time impressed on those present at COP16 to recognise:

” Without sufficient funding, we will not be able to make the significant changes needed to our economies and societies to implement the goals agreed upon and ensure a future of sustainable livelihoods. And frankly, our lives depend on meeting these goals – we have no choice. We need all wealthy nations, philanthropies, and corporations to step up to the plate.”

The statement, which can be found in full here,  is endorsed by the following 20 countries:

1.          Burkina Faso

2.          Cambodia

3.          Cameroon

4.          Côte d’Ivoire

5.          Dominica

6.          Ethiopia

7.          The Gambia

8.          Grenada

9.          Guinea

10.      Liberia

11.      Madagascar

12.      Nigeria 

13.      St. Kitts and Nevis

14.      Samoa

15.      Sierra Leone

16.      Somalia

17.      South Sudan

18.      Togo

19.      Vanuatu

20.      Zambia

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  1. Binance on July 5, 2025

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  33. PedsElite on November 1, 2025

    For instance, humor exists round unwanted effects, corresponding to a fictional account the place a feminine athlete complains about steroid use leading to unexpected development of male sexual organs. The coach’s witty reply distinguishes anabolic steroid effects from misconceptions. Healthcare suppliers prescribe them for certain conditions, corresponding to male hypogonadism and sure kinds of breast most cancers. Some athletes take anabolic steroids due to their testosterone-like effects, such as rising muscle mass and power. And it isn’t only professional athletes who’ve taken these unlawful drugs. Some adults and teens use illegal anabolic steroids to decrease physique fat, get greater muscular tissues, and enhance strength.
    Dietary fat, especially a excessive consumption of saturated fats, is understood to positively regulate testosterone and androgen manufacturing. Lastly, the slicing phase is actually a low-carb weight loss plan, with suggestions to cut 500 to 1,000 calories from the maintenance section. This part must be run till you achieve a desired physique fats share, ideally lower than 10 p.c. Every one is designed for either upkeep, acquire, or weight loss objectives.
    In general, most researchers agree that AASs can work in some people to boost muscle size and strength when mixed with a correct train program and diet (Bagatell & Brenner, 1996; Bhasin et al., 1996). By contrast, AASs most likely do not enhance efficiency of aerobic or endurance activities (Yesalis, 2000). Any of a group of synthetic medicine that resemble the male hormone testosterone. Sinner twice tested constructive for low ranges of the banned anabolic steroid clostebol – which can be used to construct muscle mass – in March 2024.
    Dr. O’Connor has over 20 years of experience treating men and women with a history of anabolic steroid, SARM, and PED use. He has been a board-certified MD since 2005 and provides guidance on harm discount methodologies. Anavar (oxandrolone) is a extremely popular anabolic steroid among women and men. Despite its high market worth, it’s typically coveted as a outcome of its versatility. Deca Durabolin causes an especially full, 3D look due to high levels of intracellular water retention filling the muscle cells on-cycle. Hair loss is more doubtless to speed up due to DHT ranges spiraling to excessive levels, causing inflammation and harm to hair follicle well being. Problem urinating may turn into a difficulty due to an enlarged prostate gland.
    The effects on the prostate, the testes, and sterility reverse when AASs are stopped; nevertheless, a minimum of one case of prostate most cancers has been reported, an exception to reversibility. Males can also develop enlarged breast tissue from taking AASs, an effect medically termed “gynecomastia” (it is referred to by male users as “bitch tits”). Gynecomastia occurs as a result of testosterone is chemically modified in the body to the feminine hormone, estrogen. Thus, the male user experiences larger quantities of estrogen than normal.
    These medicine are getting used daily by people of all ages, from center college, high school, and faculty college students to older recreational athletes. If you may be contemplating utilizing anabolic steroids for medical reasons, seek the guidance of a healthcare skilled for steerage and a prescription. If you are dealing with authorized issues associated to anabolic steroids, search authorized recommendation to understand your rights and obligations. US Authorized Types supplies templates that can assist you to navigate related authorized processes. Underneath UK legislation, anabolic steroids are categorized as Class C drugs, and may solely be legally equipped by way of prescription.
    You may additionally get thinner skin, zits, unusual hair development, and spikes in blood sugar and blood stress. Because corticosteroids turn down your immune system, taking them makes you more prone to get infections. Steroids are chemical substances, typically hormones, that your body makes naturally. The two major varieties are corticosteroids and anabolic-androgenic steroids (or anabolics for short). In kids of each sexes before the onset of puberty, AASs can initiate the characteristics of male puberty and cause the bones to stop growing prematurely. The latter effect can lead to shorter grownup heights than would in any other case occur.
    Although the variety of feminine AAS customers is considerably smaller than that of their male counterparts (estimated international lifetime prevalence price of 1.6% compared with 6.4% for males (2)), feminine strength athletes use AAS as well. These girls are inclined to perform shorter cycles, favor different AAS varieties (stanozolol, oxandrolone) and use decrease dosages. Even less knowledge than in males describe the effects of AAS use in ladies. One may extrapolate the consequences of supraphysiological androgen ranges from men to women with regard to blood pressure, erythrocytosis, lipid profile and cardiac structure. Fertility may be impaired on account of the suppressive results of AAS on gonadotropin manufacturing, inflicting disruption of the menstrual cycle.

    References:

    https://pedselite.com/best-steroids-cycle-arnold-schwarzeneggers-stack/30890/

  34. The Science Behind Cutting Supplements on November 1, 2025

    We need more correct details about the prevalence of persistent worldwide AS abuse, the results of dose and length on outcomes (and not simply markers) in human well being, and the timing and completeness of reversibility of the results of long-term AS abuse. Prospective, longitudinal studies in nations with nationwide healthcare techniques and registries are an excellent start. Our ignorance prevents rational approaches to options to AS abuse as a result of we’ve not outlined the issue and the long-term penalties. Infertility may be brought on by numerous various factors, in either the male or feminine reproductive techniques. We reviewed knowledge from an online survey of AS users and identified a sub-group who had tried to achieve a being pregnant with their partners whereas using AS.
    The use of those substances has been clinically proven to deteriorate a man’s semen high quality, in addition to to negatively impression his sexual potency- the ability to even carry out sexual intercourse. In couples the place the man has stopped taking exogenous androgens and the wife becomes pregnant, a common question is whether or not or not he can restart taking exogenous androgens in the occasion that they want to have more kids sooner or later. Rising scientific evidence means that ideally he ought to stay off all exogenous androgens while he is still interested in conceiving youngsters. When males use exogenous androgens intermittently, their sperm manufacturing sometimes rebounds every time they are “off cycle”—but usually sperm numbers and high quality don’t get well to the same baseline ranges that that they had previous to restarting the exogenous androgens. FertSteril 2023] This progressive decrease in sperm quality can impair a couple’s future fertility possibilities, so it’s best to stay with elevated endogenous production alone until the couple’s fertility efforts are complete.
    The most commonly used steroids embrace testosterone, trenbolone, boldenone, methandrostenolone, nandrolone, oxandrolone, oxymetholone, and stanozolol (8,9). HCG use in males was subsequently studied as early as 1950 and has since been shown to successfully elevate endogenous testosterone levels [56,57]. One recent study showed that hypogondal men handled with HCG monotherapy skilled a rise of their serum testosterone of roughly ~250 ng/dL with a suitable enchancment of hypogondal symptoms [57]. An further benefit of HCG is that it acts immediately on the testicle, frightening a immediate response relative to indirect medicines like CC that rely on pituitary synthesis of LH. It is because of this that HCG remedy has turn into a cornerstone in male fertility therapy. Sadly, its value, subcutaneous route of administration, and comparatively quick half-life (33 hours) prevent it from getting used for most hypogonadal patients as main therapy [58].
    Shokri et al. report a big increase in the price of apoptosis of spermatogenic cells after nandrolone administration, a rise clearly amplified by bodily train [29]. Characteristically, extra anabolic steroids present weaker AR bindings, and extra androgenic steroids strongly bind the AR, exerting a more potent impact. The authors reported an average consumption of three.1 product per particular person and per cycle in the course of the 5 to 10 weeks cycles, with doses typically being 5 to 29 instances the physiological substitute doses [8]. For males who experience persistent infertility despite cessation of steroid use and hormonal therapy, assisted reproductive technologies (ART) similar to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) may be thought-about. These methods can often overcome the barriers to fertilization caused by compromised sperm high quality or amount.
    If the patient wishes being pregnant within the next 6 months and has not but began, they need to abstain from initiating TTh till pregnancy has been achieved. If they want pregnancy inside 6 months and are already receiving TTh, it is recommended that they cease all TTh and observe a restoration regimen identical to what was detailed within the previous part. Interestingly, despite being finest identified for its use in breast most cancers, tamoxifen was initially synthesized as a potential contraceptive in 1962 within https://pedselite.com/best-workout-supplements-to-get-cut-and-gain-muscle-2022-reviews/59114/ pharmaceutical laboratories of British chemical group ICI. When it was found to actually stimulate ovulation, like clomiphene, its development was deserted until it was co-opted to be used in breast cancer in the 1980’s [63]. Not Like CC, tamoxifen is kind of lively in the periphery which is what allows for its success in treating hormone-sensitive breast cancer. It has also confirmed to be an effective remedy for early onset gynecomastia in males [64]. But similar to CC, it has been demonstrated to raise gonadotropins and improve SA parameters in sub-fertile males [65].
    In the present study, potential threat components that had been hypothesized to result in an elevated chance of AAS resumption have been examined in a cohort of ninety four male sufferers recognized with infertility secondary to persistent anabolic-androgenic use. There was a pattern that males who resumed AAS therapy had been receiving treatment for longer than patients who remained off AAS remedy. Total, our research outlines that the probability of AAS resumption in patients who chronically use anabolic steroids deserves extra clinical attention for the shared patient-provider decision-making about male infertility choices. Though it remains to be established whether there are identifiable risk factors for AAS resumption, this is the first research, to our data, that poses this question. The HAARLEM research by Smit et al. [28], involving one hundred male athletes who had taken AAS found that more than two-thirds of the members developed oligozoospermia, lowered testicular volumes, and low complete sperm depend.
    Following, we evaluated all of the out there knowledge regarding the occurring of hyperandrogenism and PCOS amongst totally different kinds of athletes and their position in the athletic efficiency. The attainable interference of such treatments in athletic performance has not been evaluated thus far. Appearance- and performance-enhancing drugs (APEDs) are substances of various chemical nature used by athletes, newbie sportsmen and body-builders to improve sports activities performance or bodily look. They include each authorized dietary supplements and illicit pharmacologic brokers [34].
    Additionally laryngeal tissue has androgen receptors, so deepening of the voice is a part of the virilisation that androgenic substances and AASs could cause in girls. Lowering of the voice is caused by progress of the larynx in girls and by thickening of the vocal chords in girls and is commonly accompanied by hoarseness [41]. Certainly, a higher rise in GH levels has been reported in exercising ladies compared to non-running girls after aerobic train [10]. Also, seek the guidance of an IVF specialist like Dr Rhythm Gupta to understand the potential side effects of steroids on fertility and get a personalized therapy. Suppression of spermatogenesis leads to testicular atrophy, which is mainly a beauty problem, though some men subsequently complain of retractile testes. The seminiferous tubule compartment of the testis, which hosts spermatogenesis, occupies about two-thirds of its quantity (186). Sex steroid-induced suppression of spermatogenesis reduces testicular quantity by sixteen.5–30.0% (176, 182, 183).
    Nonetheless, alongside the evolving number of AAS customers worldwide, the amount of misleading, misguided, and purposeful fake data has additionally grown regarding the side effects and potential treatments for male infertility and sexual dysfunction induced by AAS abuse. For example, it is not uncommon to find unsubstantiated use of “nature-based interventions” to treat AAS-induced adverse effects (Santos et al., 2022) and a lack of knowledge from clinicians relating to a practical strategy when dealing with AAS customers (Eu et al., 2023). In Accordance to most reports, the quality of sperm tends to normalize spontaneously inside 4–12 months after cessation of anabolic steroid abuse [32]. Simply stopping the use of ASA may result in the resumption of fertility in a certain proportion of male users [33, 34]. Patients can also be handled by induction of spermatogenesis with gonadotropins or gonadoliberin analogues, together with hCG IM injections, human menopausal gonadotropin (hMG) and even recombinant FSH. The use of hCG alone or in combination with hMG was reported as an effective remedy for this group of sufferers [35].
    True rates of utilization are tough to find out, as research have proven that over half of men who use anabolic steroids for non-medical reasons do not tell their physicians that they are using these substances. Nonetheless, the influence of anabolic steroid use on male fertility is sort of clear, with the overwhelming majority of men struggling a big negative influence on sperm production and quality. It is due to this fact crucial for all men using anabolic steroids to report their use to their fertility physician if they’re trying to conceive. There are some drugs, each legal and unlawful, that can have a negative impact on male fertility.

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