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Nearly 100 people have died or disappeared crossing the Central and Eastern Mediterranean so far this year – more than twice the number for the same period in 2023, the deadliest year for migrants at sea in Europe since 2016, the International Organization for Migration (IOM) said on Monday.
IOM underscored the need for regular migration pathways at a one-day summit in Rome hosted by Italy to boost development in Africa and curb migration flows.
The A Bridge for Common Life conference represented a critical opportunity to examine “unified and sustainable mechanisms to stop further needless loss of human life on treacherous routes,” said Amy Pope, the agency’s Director General, who was at the summit.
‘A stark reminder’
“Even one death is one too many,” she added, calling the latest numbers “a stark reminder that a comprehensive approach that includes safe and regular pathways – a key strategic pillar for IOM – is the only solution that will benefit migrants and States alike.”
Italy is working to strengthen its role as a bridge between Europe and Africa through a model of cooperation, development and equal partnership, IOM said, and the summit is taking place at a time when the number of people presumed to be dead or missing at sea is rising.
Missing and presumed dead
Three vessels coming from Libya, Lebanon, and Tunisia within the last six weeks carrying 158 people are unaccounted for, though IOM has recorded 73 people from these “invisible” shipwrecks as missing and presumed dead.
Last Wednesday, authorities rescued a group of 62 migrants off Cape Greco in southeastern Cyprus who had left Lebanon on 18 January. Most are hospitalized and described as severely ill, with several children in a critical condition, one of whom has since died.
Additionally, seven bodies that came ashore in Antalya, Türkiye, in recent days are believed to belong to a group of 85 migrants missing since they set off from Lebanon on 11 December.
The annual number of migrant deaths and disappearances in all the Mediterranean jumped from 2,048 in 2021, to 2,411 in 2022, and to 3,041 by the end of last year, according to IOM’s Missing Migrants Project database.
Invest in sustainable development
More than 20 leaders from Africa and the European Union, as well as representatives from UN agencies, the World Bank, and other organizations, attended the conference in the Italian capital.
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Delivering remarks, UN Deputy Secretary-General Amina Mohammed called for supporting Africa’s progress by scaling up investment to achieve the Sustainable Development Goals (SDGs), which are woefully off-track as the 2030 deadline looms.
She said this includes endorsing the $500 billion annual SDG stimulus plan put forward by the UN Secretary-General.
Reform financial system
“Accelerating sustainable development across Africa relies on a surge in private investment. The international financial institutions play a critical role in making that a reality, as does the private sector,” she added.
Ms. Mohammed also stressed the need to “refresh” international financial institutions, which were established nearly 80 years ago, so that they are fit for today.
“African countries are not represented appropriately. And the institutions are largely insufficiently responsive to their needs. It is high time to make the change needed,” she said.
“We also need new frameworks to address new technologies, and to help release their potential to accelerate progress toward the SDGs.”
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Anavar, also known by its chemical name oxandrolone, is a
synthetic anabolic steroid that has gained popularity among athletes and bodybuilders
for its reputed ability to promote lean muscle growth
while minimizing fat gain. When it comes to using Anavar specifically for fat
loss, the approach typically involves low doses that help preserve or
even build muscle mass during caloric restriction, thereby improving body composition.
The following sections detail how Anavar can be incorporated into a fat‑loss program, explain what peptides are and their
potential benefits, discuss side effects and sources, provide dosage recommendations, and touch on peptide
usage in skincare.
—
1. Using Anavar for Fat Loss
Why Anavar Is Favored
Mild Anabolic Activity: Unlike many other
steroids, Anavar has a relatively low androgenic profile, which means it is less likely to cause severe side effects such as
gynecomastia or excess acne.
High Protein‑Synthesis Efficiency: It promotes the
synthesis of protein in muscle cells, helping maintain lean tissue when calories are restricted.
Reduced Water Retention: Users report that Anavar does not cause significant fluid retention, making it easier
to see true fat loss rather than bloating.
Typical Fat‑Loss Cycle
Preparation Phase (Week 0–2)
– Focus on a high‑protein diet (~1.5 g protein per kilogram of body weight).
– Begin light cardio and resistance training, ensuring progressive overload.
Anavar Phase (Weeks 3–8)
– Dosage: Men usually start at 20 mg per day; women typically take 10–15 mg per day.
– Duration: Keep the cycle short—4 to 6 weeks—to reduce risk of liver strain and other adverse effects.
Post‑Cycle Recovery (Weeks 9–12)
– Allow at least 2–4 weeks off Anavar before considering
another cycle.
– Implement a post‑cycle therapy (PCT) if you’ve been on higher
doses or for extended periods; however, many users in the fat‑loss range do not require PCT.
How It Works
Metabolic Rate Increase: Anavar boosts basal metabolic rate slightly by enhancing mitochondrial activity.
Protein Preservation: During a caloric deficit, it helps prevent muscle catabolism, ensuring that weight loss comes primarily from fat stores.
Enhanced Recovery: Users often experience faster
recovery between workouts, allowing more frequent training sessions.
2. Peptides: An Overview
What Are Peptides?
Peptides are short chains of amino acids linked by peptide bonds.
They differ from proteins in that they usually contain fewer than 50 amino acids and can function as signaling molecules, hormones, or therapeutic agents.
Types of Common Peptides
Growth Hormone Releasing Peptides (GHRPs) – e.g., GHRP‑2,
GHRP‑6
CJC‑1295 – a long‑acting growth hormone secretagogue
BPC‑157 – promotes healing and tissue repair
Thymosin Beta‑4 – supports cell migration and angiogenesis
Melanotan II – stimulates melanin production for tanning
Ipamorelin – selective growth hormone release
Hexarelin – potent GHRP with anabolic properties
Tesamorelin – used for reducing abdominal fat in HIV patients
Selank – a neuropeptide with anxiolytic effects
Semax – cognitive enhancer and anti‑inflammatory
20 Benefits of Peptides
Stimulate growth hormone release
Promote lean muscle gain
Enhance recovery time after workouts
Reduce inflammation in joints
Improve skin elasticity and hydration
Accelerate wound healing
Support cartilage regeneration
Aid in fat loss, especially visceral fat
Increase energy levels
Improve sleep quality
Reduce cortisol production
Enhance immune function
Provide neuroprotection against oxidative stress
Promote collagen synthesis for stronger tendons
Help with hair growth and thickness
Assist in treating erectile dysfunction
Lower blood pressure via vasodilation
Support liver detoxification pathways
Increase appetite control during dieting phases
Reduce muscle soreness post‑exercise
Side Effects
Local reactions: Injection site pain, swelling, or redness.
Systemic effects: Nausea, dizziness, headaches (especially with high doses).
Hormonal imbalance: Overstimulation of growth hormone can lead to water retention or joint pain.
Allergic responses: Rare but possible in susceptible individuals.
Sources
Medical-grade peptides are available from licensed compounding
pharmacies and regulated suppliers.
Cosmetic-grade peptides may be found in beauty products, though potency and purity vary widely.
Recreational users often source peptides through online vendors; quality control is a significant risk.
Dosage & How to Use
Dosages depend on the peptide type, purpose, and user experience.
Below are general guidelines:
Peptide Typical Adult Dose (per day) Frequency
GHRP‑2 100–200 µg Twice daily
CJC‑1295 1–3 mg Once weekly (subcutaneously)
BPC‑157 250–500 µg Daily, or as directed for
injury
Tesamorelin 0.2 mg Once daily (oral or injectable)
Ipamorelin 100–200 µg Twice daily
Administration Tips
Subcutaneous injection: Use a 30‑32 gauge needle; rotate sites to
avoid lipohypertrophy.
Oral peptides: Only those specifically formulated for oral use
should be taken this way; otherwise, they may not survive the digestive tract.
Timing: For growth hormone secretagogues, taking before bedtime can harness natural circadian peaks of GH.
3. Peptides in Skincare
Peptides have become a staple ingredient in many anti‑aging and
therapeutic cosmetic products due to their ability to signal skin cells to produce collagen and other structural proteins.
How They Work on Skin
Signal Dermal Fibroblasts: Certain peptides (e.g., palmitoyl pentapeptide‑4, also known as Matrixyl) mimic the body’s natural signaling pathways that
stimulate collagen synthesis.
Promote Elastin Production: Peptides like tripeptide‑1 encourage
elastin fibers, improving skin resilience and firmness.
Reduce Inflammation: Anti‑inflammatory peptides help calm irritated or acne‑prone skin.
Common Skincare Peptides
Matrixyl (palmitoyl pentapeptide‑4)
Argireline (acetyl hexapeptide‑8) – a “botox‑like” peptide that
relaxes facial muscles
Copper tripeptide‑1 – boosts antioxidant defenses and
promotes wound healing
Hexapeptide‑9 – enhances skin elasticity
Application Guidelines
Cleanse: Remove makeup and impurities.
Apply Toner (optional): Helps with product
absorption.
Peptide Serum or Cream: Apply a pea‑sized amount, gently patting
into the skin.
Moisturizer: Seal in hydration.
Sunscreen: Essential to protect collagen from UV
damage.
Efficacy & Safety
Clinical studies show measurable improvements in wrinkle depth and skin elasticity
after 8–12 weeks of regular use.
Peptides are generally well tolerated; however, individuals with very sensitive skin may experience mild stinging upon first application.
4. Integrating Anavar and Peptide Therapy for Fat Loss
Combining Anavar with peptide therapy can amplify results when properly
managed:
Cycle Timing: Start the Anavar cycle after establishing a baseline peptide regimen (e.g., GHRP‑2
or CJC‑1295) to ensure optimal hormone levels.
Dosage Coordination: Avoid overlapping high doses of anabolic agents;
keep total protein intake high (≥1.8 g/kg).
Monitoring: Track liver enzymes, lipid profiles, and hormonal markers regularly.
Recovery Phase: After the Anavar cycle, continue peptides at maintenance levels to
sustain muscle mass and support fat loss.
5. Final Thoughts
Anavar can be a valuable tool for those looking to lose fat while preserving or building lean tissue, provided it is used responsibly
within recommended dosage limits. Peptides offer a
broad spectrum of benefits—from enhancing metabolic processes
to improving skin health—and can complement steroid therapy when applied
correctly. Always consult with a healthcare professional before
beginning any new supplement regimen, especially one involving anabolic substances or peptide hormones,
and ensure that all products are sourced from reputable manufacturers to guarantee safety and efficacy.